Rationale: Deep brain stimulation (DBS) of the hippocampus is proposed for enhancement of memory impaired by injury or disease. Many pre-clinical DBS paradigms can be addressed in epilepsy patients undergoing intracranial monitoring for seizure localization, since they already have electrodes implanted in brain areas of interest. Even though epilepsy is usually not a memory disorder targeted by DBS, the studies can nevertheless model other memory-impacting disorders, such as Traumatic Brain Injury (TBI). Methods: Human patients undergoing Phase II invasive monitoring for (...) intractable epilepsy were implanted with depth electrodes capable of recording neurophysiological signals. Subjects performed a delayed-match-to-sample (DMS) memory task while hippocampal ensembles from CA1 and CA3 cell layers were recorded to estimate a multi-input, multi-output (MIMO) model of CA3-to-CA1 neural encoding and a memory decoding model (MDM) to decode memory information from CA3 and CA1 neuronal signals. After model estimation, subjects again performed the DMS task while either MIMO-based or MDM-based patterned stimulation was delivered to CA1 electrode sites during the encoding phase of the DMS trials. Each subject was sorted (post hoc) by prior experience of repeated and/or mild-to-moderate brain injury (RMBI), TBI, or no history (control) and scored for percentage successful delayed recognition (DR) recall on stimulated vs. non-stimulated DMS trials. The subject’s medical history was unknown to the experimenters until after individual subject memory retention results were scored. Results: When examined compared to control subjects, both TBI and RMBI subjects showed increased memory retention in response to both MIMO and MDM-based hippocampal stimulation. Furthermore, effects of stimulation were also greater in subjects who were evaluated as having pre-existing mild-to-moderate memory impairment. Conclusion: These results show that hippocampal stimulation for memory facilitation was more beneficial for subjects who had previously suffered a brain injury (other than epilepsy), compared to control (epilepsy) subjects who had not suffered a brain injury. This study demonstrates that the epilepsy/intracranial recording model can be extended to test the ability of DBS to restore memory function in subjects who previously suffered a brain injury other than epilepsy, and support further investigation into the beneficial effect of DBS in TBI patients. (shrink)

In recent decades, issues that reside at the center of philosophical and psychological inquiry have been absorbed into a scientific framework variously identified as "brain science," "cognitive science," and "cognitive neuroscience." Scholars have heralded this development as revolutionary, but a revolution implies an existing method has been overturned in favor of something new. What long-held theories have been abandoned or significantly modified in light of cognitive neuroscience? _Consciousness and Mental Life_ questions our present approach to the study of consciousness and (...) the way modern discoveries either mirror or contradict understandings reached in the centuries leading up to our own. Daniel N. Robinson does not wage an attack on the emerging discipline of cognitive science. Rather, he provides the necessary historical context to properly evaluate the relationship between issues of consciousness and neuroscience and their evolution over time. Robinson begins with Aristotle and the ancient Greeks and continues through to René Descartes, David Hume, William James, Daniel Dennett, John Searle, Richard Rorty, Hilary Putnam, and Derek Parfit. Approaching the issue from both a philosophical and a psychological perspective, Robinson identifies what makes the study of consciousness so problematic and asks whether cognitive neuroscience can truly reveal the origins of mental events, emotions, and preference, or if these occurrences are better understood by studying the whole person, not just the brain. Well-reasoned and thoroughly argued, _Consciousness and Mental Life_ corrects many claims made about the success of brain science and provides a valuable historical context for the study of human consciousness. (shrink)

Available for the first time in English, this is the definitive account of the practice of sexual slavery the Japanese military perpetrated during World War II by the researcher principally responsible for exposing the Japanese government's responsibility for these atrocities. The large scale imprisonment and rape of thousands of women, who were euphemistically called "comfort women" by the Japanese military, first seized public attention in 1991 when three Korean women filed suit in a Toyko District Court stating that they had (...) been forced into sexual servitude and demanding compensation. Since then the comfort stations and their significance have been the subject of ongoing debate and intense activism in Japan, much if it inspired by Yoshimi's investigations. How large a role did the military, and by extension the government, play in setting up and administering these camps? What type of compensation, if any, are the victimized women due? These issues figure prominently in the current Japanese focus on public memory and arguments about the teaching and writing of history and are central to efforts to transform Japanese ways of remembering the war. Yoshimi Yoshiaki provides a wealth of documentation and testimony to prove the existence of some 2,000 centers where as many as 200,000 Korean, Filipina, Taiwanese, Indonesian, Burmese, Dutch, Australian, and some Japanese women were restrained for months and forced to engage in sexual activity with Japanese military personnel. Many of the women were teenagers, some as young as fourteen. To date, the Japanese government has neither admitted responsibility for creating the comfort station system nor given compensation directly to former comfort women. This English edition updates the Japanese edition originally published in 1995 and includes introductions by both the author and the translator placing the story in context for American readers. (shrink)

In this letter from the editor, the editor announces that this issue will be their last. The editor thanks those who helped along the way. 2012 APA, all rights reserved).

Commentators' criticisms are considered in relation to the aims of the book as well as in relation to the commentators' own understanding of major issues. Neither reliance on social construcitonist alternatives nor on 'de gustibus' arguments reaches the principal arguments of Praise and Blame. 2012 APA, all rights reserved).

Reviews the books, Emotion and peace of mind: From stoic agitation to Christian temptation by Richard Sorabji and Other minds by Anita Avramides . The two works considered here are deeply serious and composed by scholars who have executed their projects with undeviating integrity. In Emotion and Peace of Mind, based on his Gifford Lectures, Richard Sorabji moves the reader through a veritable course of study on a subject as notoriously protean as it is central to the lived life. The (...) twenty-six chapters range over whole realms of thought on the subject of emotion, beginning with ancient philosophy and reaching the research and theory advanced right now in that congeries of specialties dubbed the brain sciences. Between the covers of this truly estimable work one meets not just the subtle and instructive thought of Seneca and Augustine, Iamblichlus and Epictetus, but insightful commentaries on the work of Damasio, Le Doux, Maclean and others. In all, Emotion and Peace of Mind is a benchmark- volume, an outstanding contribution to the philosophy and psychology of emotion; surely a required work for anyone prepared to approach the subject with the seriousness it demands. The second book of this review, Other Minds, is a work of philosophical rigor and originality, composed by an Oxford tutor who has skillfully shaped other minds with the sharp and sharpening instrument of conceptual analysis. Do computers have minds? Do animals have minds? Are there minds other than my own? And if I know of my own mind in that most basic first-person sense, then clearly there is no other mind that I can thus know. If there is something epistemologically amiss about first-person achievements, then there is surely something suspect about claims to the effect that I know of my mind. If there is nothing less than a required first-person account of minds, then there is something epistemologically suspect about any statement of any other mind. 2012 APA, all rights reserved). (shrink)

A summary of the major arguments of PRAISE AND BLAME, both critical and constructive, is offered. The overarching objectives of the book are set forth, making clear the radical form of moral realism defended. Additional material is presented to justify the attention paid to historical vs. contemporary alternatives to moral realism, the latter found to be at once indebted to the former but often less developed. 2012 APA, all rights reserved).